Publications
Martinez Hernandez A1,2, Urbanke H1, Gillman AL3, Lee J3, Ryazanov S4,5, Agbemenyah HY6, Benito E1, Jain G1, Kaurani L5, Grigorian G7, Leonov A4,5, Rezaei-Ghaleh N4,8, Wilken P5,6,9, Arce FT3, Wagner J10, Fuhrman M10, Caruana M11, Camilleri A11, Vassallo N11, Zweckstetter M4,5,8,12, Benz R13, Giese A14, Schneider A5,6,9, Korte M15,16, Lal R17, Griesinger C18,5, Eichele G19, Fischer A20,6.
The diphenylpyrazole compound anle138b blocks Aβ channels and rescues disease phenotypes in a mouse
EMBO Mol Med. 2018 Jan;10(1):32-47. doi: 10.15252/emmm.201707825., - In press
Eva Benito6, Cemil Kerimoglu6, Binu Ramachandran, Tonatiuh Pena-Centeno, Gaurav Jain, Roman Manuel Stilling, Md Rezaul Islam, Vincenzo Capece, Qihui Zhou, Dieter Edbauer, Camin Dean, André Fischer7,'Correspondence information about the author André Fischer
RNA-Dependent Intergenerational Inheritance of Enhanced Synaptic Plasticity after Environmental Enri
Cell Reports, Volume 23, Issue 2, p546–554, 10 April 2018, - In press
Ann-Christin Wendeln, Karoline Degenhardt, Lalit Kaurani, Michael Gertig, Thomas Ulas, Gaurav Jain, Jessica Wagner, Lisa M. Häsler, Katleen Wild, Angelos Skodras, Thomas Blank, Ori Staszewski, Moumita Datta, Tonatiuh Pena Centeno, Vincenzo Capece, Md. Rezaul Islam, Cemil Kerimoglu, Matthias Staufenbiel, Joachim L. Schultze, Marc Beyer, Marco Prinz, Mathias Jucker, André Fischer & Jonas J. Neher
Innate immune memory in the brain shapes neurological disease hallmarks
Nature volume 556, pages332–338 (2018), - In press
Llorens F., Schmitz M., Knipper T., Schmidt C., Lange P., Fischer A., Zerr I
Cerebrospinal fluid biomarkers in the discrimination of Alzheimer’s disease from vascular dementia
2017 Dec;12(1):83., - In press
Benito E, Ramachandran B., Schroeder H, Schmidt G, Urbanke H. Burkhardt S, Capece C, Dean C, Fischer A
The BET/BRD inhibitor JQ1 improves brain plasticity in WT and APP mice
2017 Sep;7(9):e1239., - In press
Agís-Balboa, R.C., Pinhero, P., Rebola, N. Kerimoglu, C., Benito, E., Gertig, M., Bahari-Javan, S. Jain, G. Burkhardt, S. Delalle, I. Jatzko, A., Dettenhofer, M., Zunszain, P.A. Schmitt, A., Falkai, P. Pape, J., Binder, E.B., Mulle, C. Fischer, A., Sananbenesi, F.
Formin 2 links Neuropsychiatric Phenotypes at Young Age to an increased Risk for Dementia.
EMBO J, 2017 Oct 2;36(19):2815-28., - In press
Murdoch JD, Rostosky, CD, Gowrisankaran, S., Arora, AS, Soukup SF, Vidal R, Capece V, Freytag V, Fischer A, Verstreken P, Bonn S, Raimundo N, Milosevic, I
Endophilin-A deficiency induces the FoxO3a-Fbxo32 network and causes dysregulation of autophagy and
2016 Oct 18;17(4):1071-86., - In press
Stammler, D. Eigenbrod, T Menz, S. Frick, JS, Sweet, MJ. Shakespear, MR. Jantsch, J. Siegert, J Sabine Wölfle1, Julian D. Langer6, Ina Oehme7, Liliana Schaefer8, Klaus Heeg1, Alexander H. Dalpke1 and Fischer, A. Konrad A. Bode
Inhibition of histone deacetylases permits LPS-mediated secretion of bioactive IL-1β via a caspase-
, - In press
Ragot, A., Pietropaolo, S., Delage, S., Leinkeugel, X., Fischer, A., Cho, Y.
Genetic deletion of the Histone Deacetylase 6 exacerbates selected behavioral deficits in the R6/1 m
, - In press
Wegner, E., Brendel, C., Fischer, A. Huelsmann, S., Gärter, J., Huppke, P.
Characterization of the MeCP2/R168X knockin mouse model for Rett syndrome,
2014 Dec 26;9(12):e115444., - In press
Kerimoglu C, Sadman SM, Jain G, Benito E, Burkhardt S, Capece V, Kaurani L, Halder R,, Agís-Balboa RC, Stilling R, Urbanke U, Kranz A, Stewart AF, Fischer A.
Kmt2a and kmt2b mediate memory function by affecting distinct genomic regions.
2017 Jul 18;20(3):538-48, - In press
Paiva I, Pinho R, Pavlou MA, Hennion M, Wales P, Schütz AL, Rajput A, Szego É, Kerimoglu C, Gerhardt E, Cristina Rego A, Fischer A, Bonn S, Outeiro TF.
Sodium Butyrate Rescues Dopaminergic Cells from Alpha-Synuclein-Induced Transcriptional Deregulati
Hum Mol Genet. 2017 Mar 24, - In press
Llorens F, Thüne K, Sikorska B, Schmitz M, Tahir W, Fernández-Borges N, Cramm M, Gotzmann N, Carmona M, Streichenberger N, Michel U, Zafar S, Schuetz AL, Rajput A, Andréoletti O, Bonn S, Fischer A, Liberski PP, Torres JM, Ferrer I, Zerr I.
Altered Ca2+ homeostasis induces Calpain-Cathepsin axis activation in sporadic Creutzfeldt-Jakob dis
Acta Neuropathol Commun. 2017 Apr 27;5(1):35, - In press
Llorens F, Kruse N, Karch A, Schmitz M, Zafar S, Gotzmann N, Sun T, Köchy S, Knipper T, Cramm M, Golanska E, Sikorska B, Liberski PP, Sánchez-Valle R, Fischer A, Mollenhauer B, Zerr I.
Validation of α-Synuclein as a CSF Biomarker for Sporadic Creutzfeldt-Jakob Disease
Mol Neurobiol. 2017 Mar 21. doi: 10.1007/s12035-017-0479-5, - In press
Bahari-Javan, S., Varbanov, H., Halder, R., Benito, E., Kaurani, L. Burkhardt, S. Anderson-Schmidt, H. Anghelescu, I. Budde, M. Stilling,R.M., Costa, J. Dietrich D., Figge, C., Folkerts, H., Gade, K., Heilbronner, U., Koller, M. Konrad, C., Nussbeck, S.Y., Scherk, H., Spitze, C., Stierl, S., Stöckel, J. Thiel, J. Hagen, M., Zimmermann, J., Zitzelsberger, A., Schulz, A., Schmitt, A., Delalls, I., Falkai, P., Schulze, T.G. Dityatev, A., Sananbenesi, F., Fischer, A.
Hdac1 as a target for individualized therapy of schizophrenia patients
PNAS, 2017. 114(23):E4686-E469, - In press
Jaitner, C. Reddy, C., Abentung, A., Whittle, N., Rieder, D., Delekate, A., Korte, K., Jain, J., Fischer, A., Sananbenesi, F. Cera, I., Singewald, N., Dechant, G., Apostolova, G.
Satb2 determines miRNA Expression and Long‐Term Memory in Adult CNS
elife, 2016, eLiefe, - In press
Halder R, Hennion M, Vidal RO, Shomroni O, Rahman RU, Rajput A, Centeno TP, van Bebber F, Capece V, Vizcaino JC, Schuetz AL, Burkhardt S, Benito E, Sala MN, Javan SB, Haass C, Schmid B, Fischer A*, Bonn S.
DNA methylation changes in plasticity genes accompany the formation and maintenance of memory.
Nat Neurosci. 2016 Jan;19(1)* shared last author, - In press
Stepniak B1, Kästner A2, Poggi G1, Mitjans M1, Begemann M1, Hartmann A3, Van der Auwera S4, Sananbenesi F5, Krueger-Burg D6, Matuszko G7, Brosi C8, Homuth G9, Völzke H10, Benseler F6, Bagni C11, Fischer U8, Dityatev A7, Grabe HJ4, Rujescu D3, Fischer A12, Ehrenreich H13.
Accumulated common variants in the broader fragile X gene family modulate autistic phenotypes.
EMBO Mol Med., 2015 Nov 26;7(12):1565-79 - In press
Stammler, D. Eigenbrod, T Menz, S. Frick, JS, Sweet, MJ. Shakespear, MR. Jantsch, J. Siegert, J Sabine Wölfle1, Julian D. Langer6, Ina Oehme7, Liliana Schaefer8, Klaus Heeg1, Alexander H. Dalpke1 and Fischer, A. Konrad A.
Bode1Inhibition of histone deacetylases permits LPS-mediated secretion of bioactive IL-1β via a cas
The Journal of Immunology, - In press
Narayanan R, Pirouz M, Kerimoglu C*, Pham L, Wagener RJ, Kiszka KA, Rosenbusch J, Seong RH, Kessel M, Fischer A, Stoykova A, Staiger JF, Tuoc T.
Loss of BAF (mSWI/SNF) Complexes Causes Global Transcriptional and Chromatin State Changes in Forebr
Cell Rep. 2015 Dec 1;13(9):1842-54, - In press
Benito, E. Urbanke, U., Ramachandran, B., Barth, J. Halder, R., Awasthi, A. Jain, G., Capece, V., Burkhardt, S., Navarro-Sala, M. Nagarajan, N, Schütz, AL., Johnsen, SA. Bonn, SA Lührmann, R., Dean, C., Fischer, A.
Reinstating transcriptome plasticity and memory function in models for cognitive decline.
Journal of Clinical Investigation, (2015) 125(9):3572-84, - In press
Nagarajan S, Benito E, Fischer A, Johnsen SA.
H4K12ac is regulated by estrogen receptor-alpha and is associated with BRD4 function and inducible t
Oncotarget, 2015 Mar 30;6(9):7305-17. - In press
Ragot, A., Pietropaolo, S., Delage, S., Leinkeugel, X., Fischer, A., Cho, Y.
Inhibition of the Histone Deacetylase 6 exacerbates selected behavioral deficits in the R6/1 mouse m
Brain and Behavior, - In press
Wegner, E., Brendel, C., Fischer, A. Huelsmann, S., Gärter, J., Huppke, P.
Characterization of the MeCP2/R168X knockin mouse model for Rett syndrome.
PLoS One, - In press
Capece V, Garcia Vizcaino JC, Vidal R, Rahman RU, Pena Centeno T, Shomroni O, Suberviola I, Fischer A, Bonn S1
Oasis: online analysis of small RNA deep sequencing data.
Bioinformatics. 2015, - In press
Stilling, R.M, Benito, E., Gertig, M., Capece, V., Barth, J., Burkhardt, S., Bonn, S., Fischer, A.
De-regulation of gene expression and alternative splicing affects distinct cellular pathways in the
Frontiers in Cellular Neuroscience, 8:373. eCollection 2014. - In press
Stilling, R.M., Rönicke, R. , Benito, E., Urbanke, H. Capece, V., Burkhardt, S. Bahari-Javan, S., Barth, J., Sananbenesi, F., Schütz, A.L., Dyczkowski, J., Martinez-hernandez, a., kerimoglu, c., dent, S.Y.R., Bonn, S., Reymann, K.G., Fischer. A.
K-lysine acetyltransferase 2a regulates a hippocampal gene-expression network linked to memory forma
EMBO J. (2014), 33, 17, 1912-1927 - In press
Banzhaf-Strathmann, J., Benito, E. May, S. Arzberger, T., Tahirovic, S., Kretzschmar, H. Fischer, A., Edbauer, D
MicroRNA-125b induces tau hyperphosphorylation and cognitive deficits in Alzheimer's disease.
EMBO J., 2014;33(15):1667-80 - In press
Schmitz M, Greis C, Ottis P, Silva CJ, Schulz-Schaeffer WJ, Wrede A, Koppe K, Onisko B, Requena JR, Govindarajan N, Korth C, Fischer A, Zerr I.
Loss of Prion Protein Leads to Age-Dependent Behavioral Abnormalities and Changes in Cytoskeletal Pr
Mol Neurobiol., 2014 Mar 7. - In press
Bang C, Batkai S, Dangwal S, Gupta SK, Foinquinos A, Holzmann A, Just A, Remke J, Zimmer K, Zeug A, Ponimaskin E, Schmiedl A, Yin X, Mayr M, Halder R, Fischer A, Engelhardt S, Wei Y, Schober A, Fiedler J, Thum T.
Cardiac fibroblast-derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hyp
2014, 124(5):2136-4, - In press
Agbemenyah HY, Agis-Balboa RC, Burkhardt S, Delalle I, Fischer A
A insulin growth factor binding protein 7 is a novel target to treat dementia.
2014 Feb;62:135-43. doi: 10.1016/j.nbd.2013.09.011, - In press
Agis-Balboa RC, Fischer A.
Generating new neurons to circumvent your fears: the role of IGF signaling.
2013 Mar 30. , - [Epub ahead of print]
Sirko, S. Behrendt G, Johansson P, Tripathi P, Costa M, Bek S, Heinrich C, Tiedt S, Colak D, Dichgans M, Fischer IR, Plesnila N, Staufenbiel M, Haass C, Snapyan M, Saghatelyan A, Tsai LH, Fischer A, Grobe K, Dimou L, Götz M.
The stem cell response of reactive glia differs in diverse injury paradigms revealing a key role of
Cell Stem Cell., - In press
Kerimoglu C, Agis-Balboa R, Kranz A, Stilling R, Bahari-Javan S, Benito-Garagorri1 B, Halder R., Burkhardt S, Stewart AF & Fischer A.
Histone-methyltransferase MLL2 (kmt2b) is required for memory formation in mice.
J. Neurosci., - In press
Govindarajan N., Rao P., Burkhardt S., Sananbenesi F., Schlüter OM., Bradke F., Lu J., Fischer A.
Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer’s disease.
do10.1002/emmm.201201923., - In press
Agis-Balboa RC, Pavelka S , Kerimoglu C , Fischer A.
Loss of HDAC5 impairs memory function: Implications for Alzheimer’s disease.
Journal of Alzheimer's disease., 33(1), 2012 - In press
Bahari-Javan, S., Maddalena, A., Kerimoglu C, Wittnam, J., Held, T., Bähr, M., Burkhardt, S., Delalle, I., Kügler, S., Fischer, A.,Sananbenesi, F.
HDAC1 regulates fear extinction in mice.
J. Neurosci, 32(15):5062-73, 2012 - In press
Zovoilis A, Agbemenyah HY, Agis-Balboa RC, Stilling RM, Edbauer D, Rao P, Farinelli L, Delalle I, Schmitt A, Falkai P, Bahari-Javan S, Burkhardt S, Sananbenesi F, Fischer A.
microRNA-34c is a novel target to treat dementias.
EMBO J., 2011 Sep 23;30(20):4299-308. doi: 10.1038/emboj.20 - In press
Agis-Balboa RC, Arcos-Diaz D, Wittnam J, Govindarajan N, Blom K, Burkhardt S, Haladyniak U, Agbemenyah HY, Zovoilis A, Salinas-Riester G, Opitz L, Sananbenesi F, Fischer A.
A hippocampal insulin-growth factor 2 pathway regulates the extinction of fear memories.
2011 Aug 26;30(19):4071-83. doi: 10.1038/emboj.201, - In press
Govindarajan N, Agis-Balboa RC, Walter J, Sananbenesi F, Fischer A.
Sodium butyrate improves memory function in an Alzheimer's disease mouse model when administered at
J Alzheimers Dis., 2011;26(1):187-97. - In press
Kuczera, T., Stilling, RM., Hsia, HE., Bahari-Javan, S., Irniger, S., Nasmyth, K. Sananbenesi, F. & Fischer, A.
The Anaphase Promoting Complex is required for memory function in mice.
Learning & Memory, 18, 1:49-57, 2010 - In press
Brzózka,MM, Fischer, A., Falkai, P., Havemann-Reinecke, U.
Acute treatment with cannabinoid receptor agonist WIN55212,2 improves prepulse inhibition in psychos
Behavioural Brain Research., 218, 2 :280-7. 2010 Nov 9. - [Epub ahead of print]
Peleg, S., Sananbenesi, F., Zovoilis, A., Burkhardt, S.,Bahari-Javan, S., Agis-Balboa, R.C., Cota, P., Wittnam,JL., Doering, A., L., Salinas-Riester, G., Dettenhoffer, M., Farinelli, L., Chen, W., Fischer, A.
Altered histone H4 lysine 12 acetylation is associated with age-dependent memory impairment in mice.
328; 753, 2010, - In press
Sananbenesi, F. Fischer, A., Wang, X., Schrick, C. Neve, R. Radulovic, J. Tsai, L.H.
A hippocampal Cdk5 pathway regulates the extinction of contextual fear.
Nature Neuroscience., 10, 1012-9. (2007) - In press
Fischer A., Sananbenesi F., Wang X., Dobbin M., Tsai L.H.
Recovery of learning and memory is associated with chromatin remodeling.
Nature, 447, 178-82. (AF is corresponding author) (2007) - In press
Schrick, C, Fischer, A., Srivastava, DP, Tronson, NC., Penzes, P., Radulovic, J.
N-Cadherin regulates cytoskeletally-associated IQGAP/ERK signaling and memory formation.
Neuron, 55, 786-798 (2007) - In press
Kim D., Nguyen M.D., Dobbin M.M., Fischer A., Sananbenesi F. , Rodgers J.T., Delalle I., Baur J.A., Sui G., Armour S., Puigserver P., Sinclair D.A., Tsai L.H.
SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer’s disease and amyotro
EMBO J., 13, 3169-79 (2007) - In press
Tronson NC, Schrick C, Fischer A., Sananbenesi F, Pages G, Pouyssegur J, Radulovic J.
Regulatory Mechanisms of Fear Extinction and Depression-Like Behavior.
Neuropsychopharmacology., (2008) 33, 1570-83 - In press
Fischer A., Radulovic M, Schrick C, Sananbenesi F, Godovac-Zimmermann J, Radulovic J
Hippocampal Mek/Erk signaling mediates extinction of contextual freezing behavior.
Neurobiology of Learning and Memory., 87, 149-5 (2006) - In press
Shu T., Tseng H.C., Zhou Y., Fischer A., Stern P., Coquelle F., Reiner O., Tsai L.H.
Doublecortin-like Kinase Controls Neurogenesis by Regulating the Mitotic Spindle.
Neuron, 49, 25-39 (2006) - In press
Fischer A., Sananbenesi F., Pang P.T., Lu B., Tsai L.H.
Opposing roles of transient and prolonged expression of p25 in synaptic plasticity and hippocampus
Neuron., 48, 825-838. (2005) - In press
Park S.K., Nguyen M.D., Fischer A.[shared co-authorship], Affar E.B, Luke, M.,Dieffenbach B., Shi, Y, Tsai L.H.
Modulation of Dopamine Signaling by Prostate Apoptosis Response 4 via Direct Interaction with Dopami
Cell., 122, 275-287 (2005) - In press
Fischer A., Sananbenesi F., Schrick C., Spiess J., Radulovic J.
Distinct roles of hippocampal protein synthesis and actin rearragnement in extinction of conditioned
J.Neurosci., 24, 1962–1966 (2004) - In press
Sananbenesi F., Fischer A., Schrick C., Spiess J., Radulovic J.
Corticotropin-releasing factor receptor 2 induces mitogen-activated protein kinase signaling in the
36, 11436 –11443 (2003), - In press
Fischer A., Sananbenesi F., Schrick C., Spiess J., Radulovic J.
Regulation of contextual fear conditioning by baseline and inducible septo-hippocampal cyclin-depend
Neuropharmacology., 44, 1089-1099 (2003) - In press
Sananbenesi F., Fischer A. [shared first-authorship], Schrick C., Spiess J., Radulovic J.
Phosphorylation of hippocampal Erk-1/2, Elk-1, and p90-Rsk-1 during contextual fear conditioning: in
Mol. Cell. Neurosci., 3, 463-476 (2002) - In press
Fischer A., Sananbenesi F., Schrick C., Spiess J., Radulovic J.
Cyclin-dependent kinase 5 is required for associative learning.
J. Neurosci., 9, 3700-3007 (2002) - In press
Radulovic J., Fischer A., Katerkamp U., Spiess J.
Role of regional neurotransmitter receptors in corticotropin-releasing factor (CRF)-mediated modulat
Neuropharmacology., 39, 707-710 (2000) - In press
Sydow S., Flaccus A., Fischer A., Spiess J.
The role of the fourth extracellular domain of the rat corticotropin-releasing factor receptor type
Eur. J. Biochem., 259, 55-62 (1999) - In press